In  the parable of the vineyard, Jesus says, “Then last of all he sent his son to them, saying, ‘They will respect my son.’ But when the vinedressers saw the son, they said among themselves, ‘This is the heir. Come, let us kill him and seize his inheritance.’” (Matt. 21:37-39) The Jews were mainly responsible for crucifying the Son of God. This sealed the fate of their dispensation. God would set Israel aside as desolate (Matt. 23:37-39). He would no longer acknowledge Israel’s calling, saying of them, “For you are not my people, and I will not be your God (Hosea 1:9). Soon after the crucifixion, God has the Romans destroy Jerusalem and the temple (70 AD). The Jews are set aside by God at this present time (during the Christian dispensation), although the gifts and callings of God are irrevocable (Rom. 11:29).

More on the meaning of the cross and how it relates to Israel:

https://www.reintgenchristianbooks.com/chapter/chapter-israel-aside/

https://www.reintgenchristianbooks.com/israel-set-aside-by-god-what-does-that-mean/

https://www.reintgenchristianbooks.com/the-cross-of-christ-its-meaning-and-value/

https://www.reintgenchristianbooks.com/judaism-ends-and-christianity-is-established/